ARTERIOVENOUS MALFORMATIONS (AVM)
Arteriovenous malformations are masses of abnormal blood vessels which
grow in the brain. They consist of a blood vessel "nidus" (nest) through
which arteries connect directly to veins, instead of through the elaborate
collection of very small vessels called capillaries. Some people are born
with the nidus, but as the years go by, it tends to enlarge as the great
pressure of the arterial vessels can not be handled by the veins that drain
out of it. This causes a large collection of worm-like vessels to develop
(malform) into a mass capable of bleeding at some future time. These malformations
are most likely to bleed between the ages of 10 - 55; after 55, the chances
of bleeding diminishes rapidly. Before 55, the likelihood of hemorrhaging
is betweeen 3 and 4% per year (with a death incidence of about 1%). Once
an AVM patient has hemorrhaged, the risk of having another one might approach
20% during the first year, and gradually lessen to about 3 - 4% over the
next few years.
AVM s can occur in any area of the brain, and may be either small or large.
When they hemorrhage, they usually do so with a limited amount of blood,
unlike the hypertensive hemorrhages of other stroke patients. Loss of neurologic
function depends on both the location of the AVM and the amount of bleeding.
Many patients have very small hemorrhages, often multiple. They may display
convulsions before even knowing about the presence of an AVM. Some patients
suffer with headaches, often unrelated to the AVM which are usually found
with a CT scan or brain MRI. In rare instances, children are born with
large AVM's and are found to have heart failure because the malformation
makes the heart work beyond its capacity.
These lesions are surrounded by a very discrete layer of abnormal, nonfunctioning
brain tissue, thus allowing their removal with relative safety to the surrounding
brain. This factor is of the utmost importance to the brain surgeon, who
can take advantage of this natural separation between normal brain tissue
and the abnormal vascular malformation.
TREATMENT OPTIONS
Radiation
If there is a very small AVM, and it is deep seated in the brain, the
patient is fortunate. It is possible to give focused beam radiation to
the malformation, and avoid surgery. Within two years the malformation
will most likely disappear.
Embolization
Larger malformations may be made more surgically manageable with a technique
called embolization. With this procedure an angiogram becomes a therapeutic
tool. The interventional angiographer is capable of filling the malformation
with agents which help decrease the blood supply to the malformation (coils,
glues, plastic spheres, balloons, etc). This makes surgery easier in some
cases. The technique has been used as the primary treatment as well, and
has apparently been successful in some cases.
Surgery
Perhaps surgery is still the best way to go if the decision has been
made to do something to eliminate the AVM for good. Surgery cures these
lesions by totally removing them, thus disallowing them from ever recurring
again. The author's personal bias (quite strongly held) is that most AVM's
are best cared for with surgical removal. Even with patients who have large
and complex AVM's, surgery provides the cure when the malformation is completely
removed.
Today, with the assistance of BrainLab's most sophisticated equipment and computerized techniques, an AVM removal has been greatly facilitated. Here are two phases of an AVM removal:
- AVM Removal Part 1
- AVM Removal Part 2
Leave It Alone
Some lesions, because of their size, location or behavior are best left
alone. In these cases, your surgeon's judgment is of the utmost import.
In other cases, courses of treatment may be determined by the age or
medical condition of the patient. An example might be that of an AVM being
found in a 70-year old woman suffering headaches after her heart surgery,
having had no prior history of problems relating to the malformation. Another
example might be the case of the 52-year old businessman with a very large
and complex AVM located deep in the brain, involving the vessels that drain
to the brainstem and/or speech areas of the brain.
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I am looking for assistance in identifying further possible means that could help him.